Cart
sales@molnova.com
Bictegravir Sodium
CAS No. 1807988-02-8
Bictegravir Sodium( —— )
Catalog No. M34752 CAS No. 1807988-02-8
Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | Get Quote |
|
| 10MG | 55 | Get Quote |
|
| 25MG | 109 | Get Quote |
|
| 50MG | 211 | Get Quote |
|
| 100MG | 307 | Get Quote |
|
| 200MG | 439 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameBictegravir Sodium
-
NoteResearch use only, not for human use.
-
Brief DescriptionBictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity
-
DescriptionBictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity.
-
In VitroBictegravir sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ～6,800 in MT-2 cells and ～1,500 in MT-4 cells.
-
In Vivo——
-
Synonyms——
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV Protease
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1807988-02-8
-
Formula Weight471.36
-
Molecular FormulaC21H17F3N3NaO5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 16.67 mg/mL (35.37 mM; Ultrasonic (<60°C)
-
SMILESO=C(C([O-])=C1C2=O)C(C(NCC3=C(F)C=C(F)C=C3F)=O)=CN1C[C@@H](O4)N2[C@@H]5C[C@H]4CC5.[Na+]
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097.?
molnova catalog
related products
-
Reverse transcriptas...
Reverse transcriptase-IN-1 is a diarylbenzopyrimidine (DABP) analogue and a potent inhibitor of HIV-1 nonnucleoside reverse transcriptase with an IC50of 13.7 nM.
-
Raltegravir potassiu...
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
-
DRB
DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM).
